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ey0019.15-9 | Assorted Conditions | ESPEYB19

15.9. Genetic insights into biological mechanisms governing human ovarian ageing

KS Ruth , FR Day , J Hussain , A Martinez-Marchal , CE Aiken , A Azad , DJ Thompson , et al.

Nature. 2021;596(7872):393-7. doi: 10.1038/s41586-021-03779-7.PubMed ID: 34349265Brief summary: This study analysed genome-wide association array (GWAS) data on ~200 000 women of European ancestry to identify 290 separate genetic signals associated with normal variation in age at natural menopause (ANM). Experimental alterations of key identified genes in mouse models confirmed their impac...

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ey0016.1-1 | (1) | ESPEYB16

1.1. Genome-wide association analyses of chronotype in 697, 828 individuals provides insights into circadian rhythms

SE Jones , JM Lane , AR Wood , VT van Hees , J Tyrrell , RN Beaumont , AR Jeffries , HS Dashti , M Hillsdon , KS Ruth , MA Tuke , H Yaghootkar , SA Sharp , Y Jie , WD Thompson , JW Harrison , A Dawes , EM Byrne , H Tiemeier , KV Allebrandt , J Bowden , DW Ray , RM Freathy , A Murray , DR Mazzotti , PR Gehrman , DA Lawlor , TM Frayling , MK Rutter , DA Hinds , R Saxena , MN Weedon

To read the full abstract: Nat Commun 2019;10:343This paper reports many loci associated with chronotype (i.e. being a morning person or evening person) in a genome-wide association study (GWAS) of 697, 828 participants from the UK Biobank and 23andMe cohorts. The link between chronotype and sleep timing and quality is well known. It was therefore interestin...

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ESPE Yearbook of Paediatric Endocrinology

15.9. Genetic insights into biological mechanisms governing human ovarian ageing

1.1. Genome-wide association analyses of chronotype in 697, 828 individuals provides insights into circadian rhythms

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